Preparation of Poly-(GMA-EDA-β-CD-co-TMPTMA) Monolith as High Performance Liquid Chromatography Chiral Stationary Phase Column

Angga, Stevin C. and Septiana, Dias and Amalia, Suci and Iftitah, Elvina D. and Sabarudin, Akhmad and Warsito, Warsito (2019) Preparation of Poly-(GMA-EDA-β-CD-co-TMPTMA) Monolith as High Performance Liquid Chromatography Chiral Stationary Phase Column. Indonesian Journal of Chemistry. ISSN 1411-9420 (In Press)

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Abstract

An enantiomer molecule consisted of the chiral atom has different structure conformations, which exhibit different activities as well. Yet, its separation considerably difficult since ordinary separation could not separate both molecules. One of the popular enantioseparations which are often used was using organic polymer monolithic column modified by ethylenediamine-β-cyclodextrin (EDA-β-CD) as the enantioseparations site. The aim of this research was to produce chiral stationary phase column for enantioseparations of (±)-citronellal. It was conducted by preparing monolithic column using monomer glycidyl methacrylate (GMA), trimethylolpropane trimethacrylate (TMPTMA) as crosslinker, 1-propanol, 1,4-butanediol, and water as pore-forming agents (porogens) in the presence of α,α'-azoisobutyronitrile (AIBN) as radical initiator inside polyetheretherketone (PEEK) tubing. It was then modified with EDA-β-CD synthesized from β-CD. Finally, it was installed as a high-performance liquid chromatography column. The result shows the produced chiral stationary phase column could separate (±)-citronellal at a retention time of 44.76 and 45.71 min.

Item Type: Journal Article
Keywords: enantioseparations; cyclodextrin; organic polymer monolith; methacrylate; high-performance liquid chromatography
Subjects: 03 CHEMICAL SCIENCES > 0301 Analytical Chemistry > 030108 Separation Science
Divisions: Faculty of Mathematics and Sciences > Department of Chemistry
Depositing User: Mrs Suci Amalia
Date Deposited: 20 May 2019 05:27

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