The effect of giving formulation of red fruit oil gel emulsion (Pandanus Conoideus Lamk.) on healing speed of burns degree IIA in white male rats wistar strain (Rattus Norvegicus L.)

Anjaswara, Anggun and Inayatilah, Fidia Rizkiah and Maimunah, Siti and Annisa, Rahmi (2018) The effect of giving formulation of red fruit oil gel emulsion (Pandanus Conoideus Lamk.) on healing speed of burns degree IIA in white male rats wistar strain (Rattus Norvegicus L.). International Journal of Drug Delivery Technology, 8 (4). pp. 175-179. ISSN 0975-4415

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Abstract

Aims: The aims this study was to obtain an gel emulsion of red fruit oil in accordance with chemical physics characteristics and to know the effect oil gel emulsion preparation of red fruit on healing burn degree IIA on male wistar rats.

Methods: The design of this research used true experimental laboratory post test only control group design thats with 5 groups of treatment, with use 20 male wistar rats were given burns degree IIA and given treatment according to the group each divided into positive group (bioplasenton®), negative group (normal saline 0.9%), treatment group (gel emulsion of red fruit) concentration 3%, 5%, and 10%). The wound healing data measured on days 7, 14, and 21 and then analyzed it using one way Anova statistical test, then continued using LSD advanced test.

Results: The research results showed that oil gel emulsion of red fruit had chemical physics characteristic in accordance with gel emulsion preparation specification including organoleptic test, pH test, physical homogeneity test, spreading test, and stability test. The result of oil gel emulsion of red fruit concentration of 3%, 5% and 10% influenced the healing of burn on the statistical test of the gel emulsion treatment group did not different significantly with positive group (p<0,005), so the oil gel emulsion preparation of fruit red that equal with group positive in the healing of burns.

Conclusion: Based on the results of the study and discussion, it can be concluded that the preparation of red fruit oil emulsion gel with concentrations of 3%, 5%, 10% has chemical physics characteristics in accordance with a good gel emulsion preparation and administration of emulsion of red fruit oil concentrations of 3%, 5%, 10% for 21 days had an effect on the speed of healing male white rat wistar strain.

Item Type: Journal Article
Keywords: Red Fruit; Pandanus Conoideus Lamk.; Emulsion Gel; Emulsion; Topical; Healing of Burns
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Rahmi Annisa
Date Deposited: 22 Jul 2019 06:29

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