Formulation design and evaluation of hydrocortisone-loaded nanoemulsion and nanoemulsion gel for topical delivery

Annisa, Rahmi and Hakim, Abdul and Mutiah, Roihatul (2019) Formulation design and evaluation of hydrocortisone-loaded nanoemulsion and nanoemulsion gel for topical delivery. In: AIP Conference Proceedings. AIP Publishing, Melville, New York, 050001-1-050001-11. ISBN 978-0-7354-1860-8

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Abstract

Hydrocortisone is a corticosteroid drug used for topical atopic dermatitis treatment. Hydrocortisone has solubility on low water and also has low bioavailability. This is made in the system of nanoemulsion and nanoemulsion gel. The manufacture of hydrocortisone nanoemulsion used palm oil as an oil phase with various concentration from 10%, 12%, and 14%. This study aims to know the physicochemical characteristic and in vitro release of nanoemulsion and nanoemulsion gel. Nanoemulsion of hydrocortisone made with the emulsification method. The result shows that nanoemulsion and nanoemulsion gel of hydrocortisone with various oil phase concentration was suitable with the specified specs. The result of the particle size test of nanoemulsion formulation 1 (374 nm), 2 (395 nm), 3 (468 nm). Meanwhile, the result of the nanoemulsion gel was formulation 1 (447,8 nm), (543,2 nm), 3 (516,8 nm). Flux of nanoemulsion in vitro release test formulation 1, 2, 3 were 5,54 ± 0,24; 3,45 ± 0,43; and 3,08 ± 0,07. Whereas the gel nanoemulsion result were 2,96 ± 0,06; 2,61 ± 0,21; and 2,39 ± 0,32. The conclusion of this study is the optimal concentration of palm oil was 10% and a gel basis on nano-emulsion not affected the release of hydrocortisone.

Item Type: Book Section
Keywords: Hydrocortisone; Nanoemulsion; Topiical delivery; Gel; Formulation
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Rahmi Annisa
Date Deposited: 22 Jul 2019 06:58

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