Preparation and characterization of marigolds (Cosmos caudatus L.) leaf extract-loaded nanoemulsion: physicochemical properties and in-vitro release activities of nanoemulsion system using virgin coconut oil (VCO)

Annisa, Rahmi and Mutiah, Roihatul and Maimunah, Siti and Fauziyah, Begum (2018) Preparation and characterization of marigolds (Cosmos caudatus L.) leaf extract-loaded nanoemulsion: physicochemical properties and in-vitro release activities of nanoemulsion system using virgin coconut oil (VCO). Indian Journal of Novel Drug Delivery, 10 (3). pp. 110-116. ISSN 0975-5500

[img]
Preview
Text (full text)
4558.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview
Full text available at: http://www.ijndd.net/jul-sep-2018.html

Abstract

Marigolds (Cosmos caudatus L.) leaves widely consumed as a vegetable and empirically been used as a medicine for various diseases. In this study, nanoemulsion was prepared using leaf extract of C. caudatus with a concentration of 5%, 10%, 15% and using Virgin Coconut Oil (VCO) as an oil phase. The purpose of this study is to know the characteristics of the formulation and to determine the effect of extract concentration on the release rate of the active compound of quercetin of C. caudatus leaf extract on the preparation.C. caudatus extract was obtained by the ultrasonic method with 96% methanol solvent. Nanoemulsion extracts were made by a low energy method. All formulations were evaluated for the preparation characteristics which included organoleptic test, pH test, particle size, emulsion type, entrapment efficiency, and stability, and quercetin release test of C. caudatus leaf extract using Franz cell diffusion method with cellophane membrane.The result of the characteristic evaluation of the research shows that formulation 1, 2, and 3 give a good result that is in accordance with the standard specification of each specified. The quercetin release flux of each nanoemulsion preparation formulation was 13,374 ± 0.216 μg / cm2 / min, 9,617 ± 0.404 μg / cm2 / min and 8,635 ± 0.021 μg / cm2 / min respectively. This result shows that the higher of extract concentration, the longer the release time.

Item Type: Journal Article
Keywords: Marigolds leaf; Cosmos caudatusL.; Quercetin; Nanoemulsion; Extract Concentration; Release
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Rahmi Annisa
Date Deposited: 22 Jul 2019 06:26

Downloads

Downloads per month over past year

Origin of downloads

Actions (login required)

View Item View Item