Development of an antimicrobial gel formulation for topical delivery using silver nanoparticle

Annisa, Rahmi, Suryadinata, Arief, Nashichuddin, Ach. ORCID: https://orcid.org/0009-0006-8273-8878, Mutiah, Roihatul and Fauziyah, Begum (2019) Development of an antimicrobial gel formulation for topical delivery using silver nanoparticle. Indian Journal of Novel Drug Delivery, 11 (1). pp. 13-19. ISSN 0975-5500

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Abstract

Nanosilver is an antibacterial agent that can inhibit the growth of gram-positive bacteria such as Staphylococcus aureus. The small size makes nanosilver enhance its antibacterial properties. Nanosilver can be used as an active ingredient in topical preparations such as gels. In this study, the aim was to formulate and determine the antibacterial activity of gel nanosilver against Staphylococcus aureus. Synthesis nanosilver uses a reduction method with reducing sodium citrate and gelatin stabilizer. The Nanosilver synthesized was then characterized by UV-Vis and pectrophotometers Particle Size Analyzer (PSA). Gel preparations were nanosilver made from carbopol 940 with various concentrations of nanosilver which were 1.5%, 2%, and 2.5% which were physicochemically evaluated including organoleptic, pH, homogeneity, dispersion, viscosity, centrifugation, and cycling test at 4oC and 40oC. The antibacterial activity test was carried out by the excellent diffusion method using Nutrient Agar (NA) solid media with an incubation time of 1x24 hours at 37oC. The test bacteria used was Staphylococcus aureus. Based on the data obtained showed that the gel preparation nanosilver had physicochemical characteristics which were both organoleptically clear transparent, odorless, semisolid form, had a pH range of 5.63-5.76, homogeneous, spread power 3.3-3.83 cm, viscosity 2017-2500 cP and stocks remain stable during the period of storage and cycling test. Variations in the concentration of nanosilver in gel preparations can have an effect on inhibiting the growth of bacteria Staphylococcus aureus with inhibition by Formula 1 (1.5%) of 4.467 ± 0.275 mm, Formula 2 (2%) of 5.683 ± 0.475 mm, and Formula 3 (2, 5%) of 6.483 ± 0.425 mm.

Item Type:	Journal Article
Keywords:	Nanosilver; Nanoparticle Synthesis; Gel; Formulation; Antibacterial; Formulation
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Rahmi Annisa
Date Deposited:	22 Jul 2019 13:10

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