Profil metabolit berbagai ekstrak daun chrysophyllum cainito L. menggunakan UPLC-QTOF-MS/MS

Ma'arif, Burhan and Mutiah, Roihatul (2019) Profil metabolit berbagai ekstrak daun chrysophyllum cainito L. menggunakan UPLC-QTOF-MS/MS. Jurnal Tumbuhan Obat Indonesia, 12 (1). pp. 10-24. ISSN 2354-8797

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Chrysophyllum cainito L. is a plant which empirically used as traditional medicine. The pharmacological effect of C. cainito is caused by secondary metabolite activity contain in the leaves. The aim of this research was to know the metabolites profile in n-hexane extract, ethyl acetate extract, and methanol extract of C. cainito leaves using UPLC-QToF-MS/MS. Dried powder of C. cainito leaves was extracted with n-hexane, ethyl acetate, and methanol with gradual extraction using Ultrasonic Assisted Extraction (UAE). Each extract was prepared with methanol and DCM solvent then injected 5 µl into UPLC-QToF-MS/MS and analyzed with Masslynx 4.1 softwares and Chemspider. The result showed that there were 28 compounds from n-hexane extract with iethyltoluamide as major compound, 47 compounds from ethyl acetate extract with loliolide as major compound, and 34 compounds from methanol extract with eplerenone as major compound. Based on literature study, there were also several compounds that likely having activity as phytoestrogens.

Item Type: Journal Article
Keywords: Metabolite profiling, chrysophyllum cainito L., UPLC QToF-MS/MS
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Burhan Ma'arif
Date Deposited: 10 Dec 2019 14:37


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