Monoclonal antibodies of human zona pellucida 3 (MabhZP3) as immunocontraception candidate on connexin expression 43 (Cx43) in granulosa ovarian cell and luteinizing hormone level in the blood serum of mice (Mus musculus)

Inayatilah, Fidia (2019) Monoclonal antibodies of human zona pellucida 3 (MabhZP3) as immunocontraception candidate on connexin expression 43 (Cx43) in granulosa ovarian cell and luteinizing hormone level in the blood serum of mice (Mus musculus). drug invention today, 12 (11). pp. 2616-2623.

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Abstract

Objective: To prove that the use of Mab-hZP3 in various doses and observation time does not influence connexin
expression 43 in granulosa ovarian cell and luteinizing Hormone (LH) rate on blood serum of mice (Mus musculus).
Materials and Methods: The type of research method that is used is true experiment post-test only control group design.
This research uses 48 mice that are classified into 12. They are control (adjuvant) and treatment groups (Mab hZP3 20 µg,
40 µg, and 60 µg). The measurement of connexin 43 (Cx43) is conducted by applying immunohistochemistry method and
LH rate with enzyme-linked immunosorbent assay. Data processing technique is using analysis of variance. Results: The
giving of Mab hZP3 with a dose range 20 µg–60 µg to Cx43 expression and LH rate does not show significant difference.
Conclusion: The administration of Mab-hZP3 various doses and observation time does not contribute any effect to Cx43
expression and LH concentration of serum mice (M. musculus)

Item Type: Journal Article
Keywords: Connexin 43; immunocontraception; luteinizing hormone, monoclonal antibody; population control
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Fidia Inayatilah
Date Deposited: 10 Feb 2020 14:55

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