Estrogenic Effect of the Leaves from Katuk (Sauropus androgynus L. Merr) on Vaginal and Endometrial Atrophy in Perimenopausal Mice

Susilowati, Retno, Khoiriyah, Lailatul and Hikmah, Exma Mutatal (2020) Estrogenic Effect of the Leaves from Katuk (Sauropus androgynus L. Merr) on Vaginal and Endometrial Atrophy in Perimenopausal Mice. Pharmacognosy Journal, 12 (2). pp. 240-245. ISSN 09753575

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Full text available at: http://doi.org/10.5530/pj.2020.12.37

Abstract

To examine the potency of estrogenic effect of Katuk (or star gooseberry or sweet leaf) Sauropus androgynus L. Merr (Phyllanthaceae) leaf extract on the vaginal and endometrial atrophy in perimenopausal mice model. Methods: Completely random experiments divided into 4 groups with 5 female mice in each group: control group (N), perimenopause group which induced by 4-vynil cyclohexene dioxide (VCD) (P0), perimenopause group followed by S. androgynus leaves extract administration with 15 and 30 mg/kg BW (P15 and P30). The mice were induced to artificial perimenopause with 160 mg/kg body weight (BW) of VCD 5 times/week for 2 weeks and continuously treated with S. androgynus leaf extract for 30 days. Vaginal smear examination, maturation index (MI), vaginal epithelium and endometrial thickness were observed. Data were analyzed using a standard one-way ANOVA with LSD Test by SPSS 16.0 for Windows. Results: Administration of S. androgynus leaf extract for 30 days to perimenopausal mice model significantly decreased the duration of mice diestrus phase (p<0.01) compared to perimenopause mice. S. androgynus leaf extract treatment at dose 30 mg/kg BW led to higher vaginal epithelium thickness and maturation index compared to another group (p<0.01). The effective dose to enhance the vaginal epithelial and endometrial cells proliferation was 30 mg/ kg BW. Conclusions: S. androgynus leaf extract had a good estrogenic action that it might be useful for therapy of vaginal and endometrial atrophy caused by perimenopause effect.

Item Type: Journal Article
Keywords: Endometrial atrophy; Estrogenic effect; Laboratory mice; Perimenopause; S. androgynus leaf extract; Vaginal atrophy
Subjects: 06 BIOLOGICAL SCIENCES > 0606 Physiology > 060603 Animal Physiology - Systems
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Divisions: Faculty of Mathematics and Sciences > Department of Biology
Depositing User: Faizuddin Harliansyah
Date Deposited: 08 May 2020 14:15

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