Effect of vegetable oil on self-nanoemulsifying drug delivery system of Dayak Onion [Eleutherine palmifolia (L.) Merr.] extract using hydrophilic-lipophilic balance approach: formulation, characterization

Annisa, Rahmi, Yuwono, Mochammad and Hendradi, Esti (2020) Effect of vegetable oil on self-nanoemulsifying drug delivery system of Dayak Onion [Eleutherine palmifolia (L.) Merr.] extract using hydrophilic-lipophilic balance approach: formulation, characterization. International Journal of Drug Delivery Technology, 10 (2). pp. 210-216.

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Abstract

Eleutherine palmifolia is a typical plant of Kalimantan that has been empirically used by the Dayak people as a cure for various types of diseases. Self-nanoemulsifying drug delivery system (SNEDDS) is a drug delivery system that can be developed for onion Dayak to improve its absorption profile. Selection of oil phase, surfactant, and cosurfactant have an essential role in SNEDDS of Dayak onion. The aims of this study to determine the effect of the use of vegetable oils on SNEDDS using the HLB approach. Several 40 formulations in each oil phase with HLB ranging between 11 and 15 were screened to acquire stable SNEDDS composition without the presence of phase separation. Formulas optimal obtained F33 (HLB 14) using olive oil at a ratio formula of 1:7:2. F29 (HLB 14), using VCO at a formula ratio of 1:7:2. F14 (HLB 14) uses palm oil at a ratio formula of 2:7:1. The result showed that the optimal formula F33 (olive oil) with 58 nm of the particle size, 84.32 ± 0.00 of the transmittance percentage, 22.00 ± 0,18 of the emulsification time. Formula F29 (VCO) with 19.48 nm of the particle size, 91.78 ± 0.02 of the transmittance percentage, 43.00 ± 0.16 of the emulsification time. Formula F14 (palm oil) with 102 nm of the particle size, 90.93 ± 0.02 of the transmittance percentage, 110 ± 0.34 of the emulsification time. The optimal formula that has good characteristics and stability is the F29 (VCO) formula using tween 20/transcutol as the surfactant, PEG 400, as co-surfactant at a ratio formula of 1:7:2.

Item Type:	Journal Article
Keywords:	Dayak Onion; Eleutherine palmifolia; formulation; HLB Approach; self-nanoemulsifying; SNEEDS.
Subjects:	10 TECHNOLOGY > 1007 Nanotechnology > 100707 Nanomanufacturing
Divisions:	Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User:	Rahmi Annisa
Date Deposited:	02 Sep 2020 13:11

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