Potential of tilapia (Oreochromis niloticus) viscera bioactive peptides as antiviral for SARS-CoV-2 (COVID 19)

Riyadi, Putut Har and Tanod, Wendy Alexander and Wahyudi, Didik and Susanto, E. and Fahmi, A.S. and Aisiah, S. (2020) Potential of tilapia (Oreochromis niloticus) viscera bioactive peptides as antiviral for SARS-CoV-2 (COVID 19). Presented at International Conference on Fisheries and Marine, 13-14 July 2020, North Maluku.

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Abstract

Pandemic SARS-CoV-2 (COVID-19) is a severe problem in the world today. The SARS-CoV-2 virus contains protease and glycoprotein spike, which was used infection and development. The RBD (Receptor Binding Domain) of the glycoprotein Spike (RBD-S) can bind to the ACE2 receptor (Angiotensin Converting Enzyme-2) on the Domain protease (PD) (PD-ACE2) of the host cell causing virus infection. This study aimed to evaluate the potential of bioactive peptides from tilapia viscera hydrolysate as an antiviral peptide to attempt a simulated docking with four protein target virus COVID 19. The research was conducted by molecular docking using the PyRx software. Selected protein targets were SARS-CoV-2 protease (GDP ID: 6LU7), SPIKE COVID 19 (PDB ID: 6LVN), ACE2 (GDP ID: 6VW1), and deubiquitinase inhibitors block the SARS virus replication (PDB ID: 3E9S). The formed binding affinity was represented as a docking score. The results showed that both the Asp-Trp and Val-Tyr peptides were potential as SARS-CoV-2 antiviral, with an affinity strength equal to chloroquine and favipiravir. The Asp-Trp and Val-Tyr peptides could bind to all four receptor proteins target on the active side. Therefore, it potentially inhibits the virus sticking to proteins target that results in inhibition of virus replication. Generally, the Asp-Trp and ValTyr peptides of tilapia viscera hydrolysate are potential as an alternative antiviral peptide to medicate the infections and replication of COVID-19.

Item Type: Conference (Paper)
Subjects: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060406 Genetic Immunology
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060407 Genome Structure and Regulation
Divisions: Faculty of Mathematics and Sciences > Department of Biology
Depositing User: Didik Wahyudi
Date Deposited: 16 Nov 2020 15:51

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