Antihyperlipidemic effects of apple peel extract in high‑fat diet‑induced hyperlipidemic rats

Susilowati, Retno ORCID: https://orcid.org/0000-0001-6514-1603, Jannah, Jauharotul, Maghfuroh, Zahrotul and Kusuma, Meike Tiya (2020) Antihyperlipidemic effects of apple peel extract in high‑fat diet‑induced hyperlipidemic rats. Journal of Advanced Pharmaceutical Technology & Research, 11 (3). pp. 128-133. ISSN 2231-4040

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Abstract

Hyperlipidemia is generally managed with statin‑based drugs. Simvastatin serves as a 3‑hydroxy‑3‑methylglutaryl coenzyme A reductase (HMGR) inhibitor, with prolonged use proven to cause side effects. In the present study, antihyperlipidemic material is tested for its effect in lowering lipid in animals and its proven ability to bind to HMGR. Hyperlipidemia rats were divided into four groups, with different doses of 0, 57, and 114 mg/kg BW of apple peel extract (APE) and simvastatin (3.6 mg/kg BW). The total cholesterol (TC), total triglyceride (TG), low‑density lipoprotein cholesterol (LDLc), and high‑density lipoprotein cholesterol (HDLc) serum were measured. In silico inhibition test of HMGR activity was conducted by molecular docking using PyRx software. This process places HMGR as a receptor and active compound of apple peels as a ligand. APE treatment with a dose of 114 mg/kg BW could significantly reduce LDLc and increase serum HDLc levels. Docking tests confirmed that quercetin, chlorogenic acid, epicatechin, and catechins depicted HMGR inhibition. Quercetin could bind to HMGR at a similar location to amino acid residues as simvastatin. These material extracts have inhibited cholesterol synthesis through a stronger HMGR inhibition than simvastatin.

Item Type:	Journal Article
Keywords:	qntihyperlipidemic; apple peels; high‑density lipoprotein cholesterol; hydroxy‑3‑methylglutaryl coenzyme A reductase; low‑density lipoprotein cholesterol; triglyceride
Subjects:	11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics
Divisions:	Faculty of Mathematics and Sciences > Department of Biology
Depositing User:	Retno Susilowati
Date Deposited:	22 Nov 2020 19:12

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