The effect ethanol extract of Calotropis gigantean root in increasing the level of IFN-y and the expression of casppase 3 on mice (Mus musculus L.) with fibrosarcoma

Muchtaromah, Bayyinatul and Setiawan, Andri and Romaidi, Romaidi and Mutiah, Roihatul and Kristanti, Risma Aprinda (2019) The effect ethanol extract of Calotropis gigantean root in increasing the level of IFN-y and the expression of casppase 3 on mice (Mus musculus L.) with fibrosarcoma. International Journal of Engineering & Technology, 8 (19). pp. 169-273. ISSN 2227-524X

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Abstract

Calotropis gigantea is one of the traditional medicine especially used for cancer treatment. This study aimed to evaluate the effect of ethanol extract of C. gigantea root in increasing the level of IFN-γ and the expression of Caspase 3 as a scientific evidence. The ethanol extract at dosage of 50, 100 and 150 mg/kg bw were given daily for several weeks on the mice induced by 7,12-dimethylbenz(α) anthracene (DMBA). The result revealed that the dosage of 150 mg/kg bw significantly could increase the level of IFN-γ and the expression of Caspase 3. In addition, the dosage 150 mg/kg bw also increases the body weight especially after induction of DMBA. This result indicate that the active ingredients of C. gigantea root have a function as immunomodulator agent to increase immune system, initiate apoptosis process and make proliferation disfunction by increasing IFN-γ and Caspase 3. This finding showed that C gigantea useful for the treatment of fibrosarcoma better than methotrexate as anticancer medicine standard.

Item Type: Journal Article
Keywords: Calotropis gigantea; fibrosarcoma; DMBA; Caspase 3; IFN-γ.
Subjects: 06 BIOLOGICAL SCIENCES > 0608 Zoology > 060802 Animal Cell and Molecular Biology
Divisions: Faculty of Mathematics and Sciences > Department of Biology
Depositing User: Bayyinatul Muchtaromah
Date Deposited: 28 Nov 2020 03:58

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