Anticancer activity in 2-methoxy-4-((4-methoxy-phenilimino)-methyl)-phenol compound on T47D breast cancer cells

Sukria, Laila and Hayati, Elok Kamilah and Hanapi, Ahmad and Adawiyah, Robiatul and Ningsih, Rachmawati (2020) Anticancer activity in 2-methoxy-4-((4-methoxy-phenilimino)-methyl)-phenol compound on T47D breast cancer cells. Presented at The 10th International Conference on Green Technology (ICGT) "Empowering the Fourth Industrial Revolution through Green Science and Technology", 2-3 October 2019, Malang, Indonesia.

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Abstract

2-methoxy-4-((4-methoxyphenilimino)-methyl)-phenol compound is a Schiff base compound synthesized from vanillin and p-anisidin. The purpose of this research is to determine the stability of the 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol compound and to test the anticancer activity of 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol in inhibiting T47D breast cancer cells. The stability of the 2-methoxy-4-((4-methoxy-phenylimino)-methyl)-phenol compound was carried out by characterization using chemical tests, identification using FTIR and GC-MS. While the anticancer activity test of compound 2-methoxy-4-((4-methoxifenilimino) methyl) phenol using the MTT method. The results of re-characterization using chemical tests, identification of FTIR and KG-SM showed the compound was still stable. The IC50 value of compound 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol was 353,038 μg / mL which showed weak activity in inhibiting T47D breast cancer cells.

Item Type: Conference (Paper)
Keywords: anticancer activity; 2-methoxy-4-((4-methoxy-phenilimino)-methyl)-phenol
Subjects: 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030504 Organic Green Chemistry
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111506 Toxicology (incl. Clinical Toxicology)
Divisions: Faculty of Mathematics and Sciences > Department of Chemistry
Depositing User: Elok Kamilah Hayati
Date Deposited: 28 Nov 2020 04:16

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