Mimba leaf therapy causes high level of TGF-β expression and low expression of TNF-α in the spleen of Mencit in infection of Plasmodium berghei

Rahmah, Zainabur and Indrawan, Doby (2020) Mimba leaf therapy causes high level of TGF-β expression and low expression of TNF-α in the spleen of Mencit in infection of Plasmodium berghei. Presented at International Conference on Agromedicne & Tropical Diseases, 12-13 Sep 2020, Jember.

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Abstract

Background: Malaria infection is still one of the world's health problems caused by the brightness of the mortality rate (20.9%-50%). One reason is Plasmodium
falciparum is resistant to conventional anti-malarial drugs. Neem leaves have an antimalarial effect by decreasing parasitemia, but there have been no reports of their effects in increasing the expression of beta TGF-β in the plasma and spleen tissue.This study to determine the effect of neem leaf extract on increasing TGF-β expression and decreasing TNF-α expression in mice infected with Plasmodium berghei infection.
Methods: Results: In this study there were four groups, namely Treatment 1 = (infected with Plasmodium berghei without treatment). Treatment 2 = (in Plasmodium berghei infection and treated with neem leaves at a dose of 0.25 mg / gr BB). Treatment 3 = (in Plasmodium berghei infection and treated with neem leaves at a dose of 0.5 mg / gr BB). Treatment 4 = (in Plasmodium berghei infection and treated with neem leaves at a dose of 1 mg / gr BB). TGF-β examination with Elisa and TNF-α examination with immunohistochemistry.
Results : In groups in plasmodium berghei infection without therapy of neem leaves showed a decrease in TGF-β expression in plasma and spleen tissue. Whereas in the group treated with neem leaves as much as 1 mg / gr BB showed high expression of TGF-β and decreased expression of TNF-α.
Conclusion: Neem leaf therapy can increase TGF-β expression and decrease TNF-α expression in spleen.

Item Type: Conference (Paper)
Keywords: Plasmodium berghei; transforming growth factor-; tumor necrosis factor-α
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1118 Diseases > 111803 Parasitic Diseases
Divisions: Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User: Dr Zainabur Rahmah
Date Deposited: 30 Nov 2020 09:25

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