Pengembangan Sistem Nanostructured Lipid Carrier (NLC) daun Chrysanthemum cinerariifolium (Trev.) Vis dengan variasi konsentrasi lipid

Listiyana, Anik and Mutiah, Roihatul and Suryadinata, Arief and Salsabilla, Farida Rahma (2020) Pengembangan Sistem Nanostructured Lipid Carrier (NLC) daun Chrysanthemum cinerariifolium (Trev.) Vis dengan variasi konsentrasi lipid. Journal of Islamic Medicine, 4 (2). pp. 86-97. ISSN 2550-0074

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Abstract

Ethanol extract 96% of Chrysanthemum cinerariifolium (Trev.) Vis leaves are proven to have anticancer activity. However, these compounds have low solubility in water and fat. To improve the bioavailability of preparations, the development of drug design in the form of Nanostructured Lipid Carrier (NLC) is carried out.The aim this study was to determine the effect of differences in lipid concentration of Monostearin and Oleic Acid in the formulation of the NLC system of Chrysanthemum cinerariifolium (Trev.) Vis leaves, which produced good physicochemical characteristics including organoleptic characteristics, pH, viscosity, particle size, and drug entrapment efficiency. Making is done using the High Shear Homogenization method. Organoleptic tests showed ideal results for the Nanostructured Lipid Carrier (NLC) system, the resulting pH values in formula 1 (7.0 ± 0.12), formula 2 (6.7 ± 0.17) and formula 3 (6.8 ± 0.2)), the viscosity value of formula 1 (55.66 ± 2.84 cPs), formula 2 (28.86 ± 3.91 cPs), and formula 3 (28.57 ± 16.85 cPs). Particle size of formula 1 (5530 ± 320.47 nm), formula 2 (5337 ± 671.44 nm) and formula 3 (4676 ± 2215.75 nm)). The entrapment efficiency value of formula 1 drugs (33.55%), formula 2 (38.77%), formula 3 (83.75%). Based on the characterization result, the best formula was obtained at a lipid concentration of 10%, which was used for the formula of the NLC system of Chrysanthemum cinerariifolium (Trev.) Vis leaves for oral anticancer preparations

Item Type: Journal Article
Additional Information: -
Keywords: Nanostructured Lipid Carrier (NLC); Lipids; 96% ethanol extract of Chrysanthemum cinerariifolium (Trev.) Vis leaves; Characterization
Subjects: 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences
Divisions: Faculty of Medical and Health Sciences > Department of Medical Education
Depositing User: Anik Listiyana
Date Deposited: 03 Dec 2020 06:00

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