Immunomodulatory activity of exopolysaccharides produced by Leuconostoc mesenteroides strains isolated from palm (Borassus flabellifer L.) sap

Ma'unatin, Anik and Harijono, Harijono and Zubaidah, Elok and Rifa'i, Muhaimin (2020) Immunomodulatory activity of exopolysaccharides produced by Leuconostoc mesenteroides strains isolated from palm (Borassus flabellifer L.) sap. Presented at The 10th International Conference on Green Technology (ICGT) "Empowering the Fourth Industrial Revolution through Green Science and Technology", 2-3 October 2019, Malang, Indonesia.

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Abstract

This study was to evaluate the immunomodulatory effects of exopolysaccharides (EPS) produced by Leuconostoc mesenteroides strains isolated from palm (Borassus flabellifer L.) sap. The EPS used were produced by two strains of Leuconostoc mesenteroides (N5 and N7) on different medium which were palm sap (EPS NSN5 and EPS NSN7) and MRS supplemented with sucrose (EPS MSN5 and EPS MSN7). EPS were given to BALB/c mice before infected by lipopolysaccharide (LPS). The results of flow cytometric analysis of spleen lymphocytes showed some EPS were able to increased cytokines production (IL-2, INF-γ and TNF-α) by CD4+ cells. IL-2 production decreased with EPS NSN5 and EPS NSN7, INF-γ decreased with EPS MSN7 while TNF-α decreased with EPS NSN7. These results indicated that the EPS produced by two strains of Leuconostoc mesenteroides have immunomodulatory activity.

Item Type: Conference (Paper)
Keywords: exopolysaccharides;immunomodulator; Leuconostoc mesenteroides; Borassus flabellifer L.
Subjects: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules
Divisions: Faculty of Mathematics and Sciences > Department of Chemistry
Depositing User: Anik Ma'unatin
Date Deposited: 11 May 2021 04:47

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