Association between GPER gene polymorphisms and GPER expression levels with cancer predisposition and progression

Ulhaq, Zulvikar Syambani, Soraya, Gita Vita, Milliana, Alvi and Tse, William Ka Fai (2021) Association between GPER gene polymorphisms and GPER expression levels with cancer predisposition and progression. Heliyon, 7 (3). pp. 1-8. ISSN 24058440

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Abstract

Estrogen is a female sex steroid hormone that plays a significant role in physiological functions. Evidence suggests that estrogen-signaling pathways are closely linked to cancer development and progression. The novel G proteincoupled estrogen receptor (GPER or GPR30) has been shown to influence cancer predisposition and progression, although results of related studies remain equivocal. Thus, this meta-analysis aimed to estimate the relationship between GPER gene polymorphisms and GPER expression levels, with cancer predisposition and progression. The pooled results showed that two GPER polymorphisms, rs3808350 and rs3808351, were significantly associated with cancer predisposition, especially in the Asian population, but no significant association was detected for rs11544331. In parallel, we also found that cancer aggressiveness and progression correlated with rs3808351 and GPER expression in cancerous tissues. Altogether, our findings suggest that GPER plays a pivotal role in cancer pathogenesis and progression. We suggest that rs3808350 and rs3808351 may be used as a prospective biomarker for cancer screening; while rs3808351 and GPER expression can be used to examine the prognosis of patients with cancer. Further biological studies are warranted to confirm our findings.

Item Type:	Journal Article
Keywords:	estrogen; GPER; cancer malignancies; predisposition; progression
Divisions:	?? JDok ??
Depositing User:	Alvi Alvi Milliana
Date Deposited:	01 Jul 2021 08:30

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