Anticancer activity in 2-methoxy-4-((4-methoxy-phenilimino)methyl)-phenol compound on T47D breast cancer cells

Sukria, Laila, Hayati, Elok Kamilah, Hanapi, Ahmad, Adawiyah, Robiatul and Rachmawati, Ningsih (2020) Anticancer activity in 2-methoxy-4-((4-methoxy-phenilimino)methyl)-phenol compound on T47D breast cancer cells. Presented at International Conference Green Tecnology, October 2019, Malang, Indonesia.

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Abstract

2-methoxy-4-((4-methoxyphenilimino)-methyl)-phenol compound is a Schiff base compound synthesized from vanillin and p-anisidin. The purpose of this research is to determine the stability of the 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol compound and to test the anticancer activity of 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol in inhibiting T47D breast cancer cells. The stability of the 2-methoxy-4-((4-methoxy-phenylimino)-methyl)phenol compound was carried out by characterization using chemical tests, identification using FTIR and GC-MS. While the anticancer activity test of compound 2-methoxy-4-((4methoxifenilimino) methyl) phenol using the MTT method. The results of re-characterization using chemical tests, identification of FTIR and KG-SM showed the compound was still stable. The IC50 value of compound 2-methoxy-4-((4-methoxyphenilimino) methyl) phenol was 353,038 μg / mL which showed weak activity in inhibiting T47D breast cancer cells.

Item Type:	Conference (Paper)
Keywords:	Anticancer activity ,2-methoxy-4-((4-methoxy-phenilimino)methyl)-phenol ,T47D cells
Subjects:	03 CHEMICAL SCIENCES > 0301 Analytical Chemistry > 030104 Immunological and Bioassay Methods 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030503 Organic Chemical Synthesis 03 CHEMICAL SCIENCES > 0305 Organic Chemistry
Depositing User:	Elok Kamilah Hayati
Date Deposited:	13 Jul 2021 11:36

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