The Marker Active Compound Identification of Calotropis gigantea Roots Extract as an Anticancer

Mutiah, Roihatul and Sukardiman, Sukardiman and Widyawaruyanti, Aty (2016) The Marker Active Compound Identification of Calotropis gigantea Roots Extract as an Anticancer. International Journal Pharmacological and Pharmaceutical Sciences, 3 (11).

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Abstract

Calotropis gigantiea (L.) R. Br (Apocynaceae) commonly called as “Biduri” or “giant milk weed” is a well-known weed to many cultures for treating various disorders. Several studies reported that C.gigantea roots has anticancer activity. The main aim of this research was to isolate and identify an active marker compound of C.gigantea roots for quality control purpose of its extract in the development as anticancer natural product. The isolation methods was bioactivity guided column chromatography, TLC and HPLC. Evaluated anticancer activity of there substances using MTT assay methods. Identification structure active compound by UV, 1HNMR, 13CNMR, HMBC, HMQC spectral and other references. The result showed that the marker active compound was identical as Calotropin.

Item Type: Journal Article
Keywords: calotropin; Calotropis gigantea; marker active; anticancer
Subjects: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
Divisions: Faculty of Medical and Health Sciences > Department of Pharmacy
Depositing User: Dr. M.Kes. Roihatul Muti'ah
Date Deposited: 03 Jan 2017 09:02

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