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Ma'arif, Burhan 
ORCID: https://orcid.org/0000-0001-9182-343X, Jing, Seow L., Wafi, Abdul ORCID: https://orcid.org/0000-0002-9717-0094, Maulina, Novia, Subiakto, Erlangga S. and Taek, Maximus M.
(2026)
Development of an ethnopharmacognosy-based traditional herbal hair growth formula from East Nusa Tenggara: A multiparametric in vivo evaluation.
Tropical Journal of Natural Product Research, 10 (9).
pp. 11428-11436.
ISSN 2616-0692
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Abstract
Chemotherapy-induced alopecia is a visible and psychologically distressing adverse effect of anticancer therapy, supporting the search for safer and culturally relevant hair-growth interventions. This study evaluated an East Nusa Tenggara ethnomedicinal herbal formulation containing Aleurites moluccanus, Hibiscus rosa-sinensis, Ficus benjamina, Polyscias scutellaria, and Hibiscus tiliaceus in a croton oil-induced inflammatory alopecia model. Two independent male mouse cohorts were used to assess clinical hair growth score, hair length, hair weight, and hair follicle thickness, with 5% minoxidil and vehicle-treated groups as comparators. The formulation produced higher clinical hair growth scores than 5% minoxidil from days 3 to 7, although its day-8 score was lower than that of minoxidil (2.17 ± 0.24 versus 2.83 ± 0.24), and produced the highest day-28 hair length at 6.3 ± 0.8 mm. Welch analysis of variance showed a significant difference in day-28 hair length among groups (p = 0.001), with greater values than minoxidil and untreated normal control. Hair weight increased earlier during the third week, although endpoint values were comparable with minoxidil and vehicle-containing controls. Histological analysis showed the highest hair follicle thickness in the formulation group at 47.04 ± 7.64 µm, with a significant overall treatment effect (p = 0.013) and significant differences from all comparator groups after adjustment. These findings support further development of this ethnomedicinal formulation as a plant-based topical preparation for alopecia management.
| Item Type: | Journal Article |
|---|---|
| Keywords: | ethnomedicine; chemotherapy-induced alopecia; clinical hair growth score; hair length; hair weight; hair follicle thickness |
| Subjects: | 11 MEDICAL AND HEALTH SCIENCES > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences |
| Divisions: | Faculty of Medical and Health Sciences > Department of Pharmacy |
| Depositing User: | Burhan Ma'arif |
| Date Deposited: | 06 Oct 2026 13:18 |
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