Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology

Barroroh, Himmatul and Dewi, Ayu and Hasanah, Hafidatul and Jannah, Akyunul and Dewi, Diana Candra and Fasya, A, Ghanaim and Amalia, Suci and Maunatin, Anik (2020) Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology. Presented at 1st International Conference on Islam, Science and Technology (ICONIST), 22 Oct 2018, Batu, East of Java, Indonesia.

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Abstract

The aim of this research is to know the effect of short-term bitter melon (Momordica Charantia L.) fruit concentrated infusions therapy on the histology of alloxan-induced rat kidney glomerulus. Renal glomerular histology was observed using Hematoxylin-Eosin (HE) test. A therapeutic dose of bitter melon fruit concentrated therapy used was 0.15 mL/200 g BW; 0.30 mL/200 g BW; 0.45 mL/200 g BW; 0.60 mL/200 g BW; 0.80 mL/200 g BW and 1 mL/200 g BW. The results showed that the bitter melon fruit concentrated infusions therapy on alloxan-induced DM rats was able to decrease the Blood Glucose Levels (BGL) of the treated rats in varying degrees. The therapy also successfully repairs the damage kidney glomerulus cells of all rats treated with an average bowman's space improvement of 110% of healthy rat's kidney glomerulus cells. It appears that the mechanism of the bitter melon active substance in reducing the BGL occurs through a different path to its mechanism in repairing damaged glomerulus cells.

Item Type: Conference (Speech)
Keywords: diabetes mellitus; extract; bitter melon; momordica; hematoxylin; eosin; he; therapy; blood glucose levels; natural product; alloxan; kidney
Subjects: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
11 MEDICAL AND HEALTH SCIENCES > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified
Divisions: Faculty of Mathematics and Sciences > Department of Chemistry
Depositing User: Himmatul Barroroh
Date Deposited: 24 Jul 2020 15:24

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